Journal
BMC NEPHROLOGY
Volume 18, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12882-016-0422-4
Keywords
CKDu; Mesoamerican nephropathy; Follow-up; Community-based; Nicaragua
Categories
Funding
- UK Colt Foundation
- Dutch National Postcode Lottery
- Welcome Trust Institutional Strategic Support Fund [097834/Z/11/B]
- Welcome Trust Senior Research Fellowship in Clinical Science [098504/Z/12/Z]
- Wellcome Trust [097834/Z/11/B] Funding Source: Wellcome Trust
- Medical Research Council [MR/K006584/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0510-10090, CL-2010-18-001] Funding Source: researchfish
Ask authors/readers for more resources
Background: An epidemic of Mesoamerican Nephropathy (MeN) is killing thousands of agricultural workers along the Pacific coast of Central America, but the natural history and aetiology of the disease remain poorly understood. We have recently commenced a community-based longitudinal study to investigate Chronic Kidney Disease (CKD) in Nicaragua. Although logistically challenging, study designs of this type have the potential to provide important insights that other study designs cannot. In this paper we discuss the rationale for conducting this study and summarize the findings of the baseline visit. Methods: The baseline visit of the community-based cohort study was conducted in 9 communities in the North Western Nicaragua in October and November 2014. All of the young men, and a random sample of young women (aged 18-30) without a pre-existing diagnosis of CKD were invited to participate. Glomerular filtration rate (eGFR) was estimated with CKD-EPI equation, along with clinical measurements, questionnaires, biological and environmental samples to evaluate participants' exposures to proposed risk factors for MeN. Results: We identified 520 young adults (286 males and 234 females) in the 9 different communities. Of these, 16 males with self-reported CKD and 5 females with diagnoses of either diabetes or hypertension were excluded from the study population. All remaining 270 men and 90 women, selected at random, were then invited to participate in the study; 350 (97%) agreed to participate. At baseline, 29 (11%) men and 1 (1%) woman had an eGFR < 90 mL/min/1.73 m(2). Conclusion: Conducting a community based study of this type requires active the involvement of communities and commitment from local leaders. Furthermore, a research team with strong links to the area and broad understanding of the context of the problem being studied is essential. The key findings will arise from follow-up, but it is striking that 5% of males under aged 30 had to be excluded because of pre-existing kidney disease, and that despite doing so 11% of males had an eGFR < 90 mL/min/1.73 m2 at baseline.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available