Journal
BIO-PROTOCOL
Volume 7, Issue 17, Pages -Publisher
BIO-PROTOCOL
DOI: 10.21769/BioProtoc.2525
Keywords
LLPS; Amyotrophic lateral sclerosis; Peptides; Arginine; Phase separation; Mass spec; C9orf72; Stress granule
Categories
Funding
- KU Leuven
- VIB
- European Research Council [340429]
- Research Foundation Flanders (FWO) [G.0983.14N, G.0029.12]
- Interuniversity Attraction Poles Programme P7/16
- Association Belge contre les Maladies Neuro-Musculaires (ABMM)
- ALS Liga (Belgium)
- 'Opening the Future' Fund
- Agency for Innovation by Science and Technology (IWT)
- European Research Council (ERC) [340429] Funding Source: European Research Council (ERC)
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Studying liquid-liquid phase separation (LLPS) of proteins provides key insights into the biogenesis of membraneless organelles and pathological protein aggregation in disease. We have established a protocol for inducing the phase separation of arginine-rich peptides, which allows for studying their molecular determinants and dynamics (Boeynaems et al., 2017).
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