Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 35, Pages 29562-29570Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b09916
Keywords
3D printing; bone implants; titania nanotubes; anodization; bone cancer
Funding
- Australian Government Training Program Scholarship
- ARC
- Forrest George and Sandra Lynne Young Supplementary Scholarship
- Australian Research Council (ARC) [DP120101680, FT110100711]
- School of Chemical Engineering, the University of Adelaide
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Primary and secondary bone cancers are major causes of pathological bone fractures which are usually treated through implant fixation and chemotherapy. However, both approaches face many limitations. On one hand, implants may suffer from poor osseointegration, and their rejection results in repeated surgery, patient's suffering, and extensive expenses. On the other hand, there are severe systemic adverse effects of toxic chemotherapeutics which are administrated systemically. In this paper, in order to address these two problems, we present a new type of localized drug-releasing titanium implants with enhanced implants' biointegration and drug release capabilities that could provide a high concentration of anticancer drugs locally to treat bone cancers. The implants are fabricated by 3D printing of Ti alloy followed by an anodization process featuring unique micro- (particles) and nanosurface (tubular arrays) topography. We successfully demonstrate their enhanced bone osseointegration and drug loading capabilities using two types of anticancer drugs, doxorubicin (DOX) and apoptosis-inducing ligand (Apo2L/TRAIL). In vitro study showed strong anticancer efficacy against cancer cells (MDA-MB-231-TXSA), confirming that these drug-releasing implants can be used for localized chemotherapy for treatment of primary and secondary bone cancers together with fracture support.
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