Journal
CHEMICAL SCIENCE
Volume 8, Issue 5, Pages 3586-3592Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc00468k
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Funding
- EPSRC [EP/100548X/1]
- ERC [ERC-STG-259711]
- Marie Curie Foundation
- EPSRC [EP/I00548X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I00548X/1] Funding Source: researchfish
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The development of a ligand-assisted Pd-catalyzed C-H alkenylation of aliphatic amines is reported. Our studies indicated that an amino-acid-derived ligand renders the C-H bond activation step reversible and promotes the traditionally difficult alkenylation process. The C(sp(3))-H alkenylation proceeds through a 5-membered-ring cyclopalladation pathway that allows access to complex aliphatic heterocycles that could be useful to practioners of synthetic and medicinal chemistry.
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