Journal
CHEMICAL SCIENCE
Volume 8, Issue 9, Pages 6202-6206Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc02112g
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21325207, 21532003, 21421062]
- 111 project of the Ministry of Education of China [B06005]
Ask authors/readers for more resources
A bioinspired enantioselective synthesis of crinine-type alkaloids has been developed by iridium-catalyzed asymmetric hydrogenation of racemic cycloenones. The method features a biomimetic stereodivergent resolution of the substrates bearing a remote arylated quaternary stereocenter. Using this protocol, 24 crinine-type alkaloids and 8 analogues were synthesized in a concise and rapid way with high yield and high enantioselectivity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available