Journal
CHEMICAL SCIENCE
Volume 8, Issue 3, Pages 2381-2386Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc04824b
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Funding
- JSPS
- World Premier International Research Initiative (WPI), MEXT of Japan
- Grants-in-Aid for Scientific Research [14F04339] Funding Source: KAKEN
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A new carbon monoxide (CO)-releasing material has been developed by embedding amanganese carbonyl complex, MnBr(bpydc)(CO)(3) (bpydc = 5,5'-dicarboxylate- 2,2'-bipyridine) into a highly robust Zr(IV)-based metal-organic framework (MOF). Efficient and controllable CO-release was achieved under exposure to low intensity visible light. Size-controllable nanocrystals of the photoactive MOF were obtained and their CO-releasing properties were correlated with their crystal sizes. The photoactive crystals were processed into cellular substrates with a biocompatible polymer matrix, and the light-induced delivery of CO and its subsequent cellular uptake were monitored using a fluorescent CO-probe. The results discussed here demonstrate a new opportunity to use MOFs as macromolecular scaffolds towards CO-releasing materials and the advantage of MOFs for high CO payloads, which is essential in future therapeutic applications.
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