4.8 Article

Metal-free O-H/C-H difunctionalization of phenols by o-hydroxyarylsulfonium salts in water

Journal

CHEMICAL SCIENCE
Volume 8, Issue 2, Pages 1601-1606

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc04504a

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Funding

  1. National Key Research and Development Program [2016YFD0600801]
  2. Natural Science Foundation of China [21502094]
  3. Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

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An environmentally benign method for C-H/O-H difunctionalization of phenols with sulfoxides under mild conditions has been developed. The reaction process is mediated by an electrophilic aromatic substitution and subsequent selective aryl or alkyl migration, involving C-S and C-O bond formations with broad substrate scope.

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