Journal
CHEMICAL SCIENCE
Volume 8, Issue 1, Pages 40-62Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc02118b
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Funding
- Pfizer Worldwide Medicinal Chemistry
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Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder (R) databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.
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