Journal
CHEMICAL SCIENCE
Volume 8, Issue 10, Pages 7246-7250Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc03293e
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Funding
- State Key Laboratory of Elemento-Organic Chemistry
- National Key Research and Development Program of China [2016YFA0602900]
- NSFC [21421062, 21522205, 21672110]
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The first total syntheses of schilancidilactones A and B, schilancitrilactone A, and 20-epi-schilancitrilactone A have been accomplished using a nickel-catalyzed cross coupling of alkyl bromide with vinyl stannane as the final step. The other key steps include late-stage C( sp(3))-H bromination, the oxidative cleavage of a diol to provide the requisite ketone and ester for schilancidilactones A and B, and Dieckmann-type condensation to generate the A ring of schilancitrilactone A and 20-epi-schilancitrilactone A.
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