Journal
CHEMICAL SCIENCE
Volume 8, Issue 7, Pages 4917-4925Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc00475c
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Funding
- National Natural Science Foundation of China [31330059, 31171649, 31271834, 31371824, 31401631, 31601446]
- National Institutes of Health [NIGMS R01GM114418-01A1]
- Deutsche Forschungsgemeinschaft [INST 187/621-1]
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Monascus azaphilone pigments (MonAzPs) are very widely used as food colorants, but their biosynthetic pathway has remained poorly characterized for more than half a century. In this study, the individual steps of MonAzPs biosynthesis in Monascus ruber M7 were elucidated by a combination of targeted gene knockouts, heterologous gene expression, and in vitro chemical and enzymatic reactions. This study describes the first rational engineering of MonAzPs biosynthesis and provides a roadmap for future pathway engineering efforts directed towards the selective production of the most valuable pigments and serves as a model for the biosynthesis of fungal azaphilones in general.
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