Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 38, Pages 11440-11444Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201705368
Keywords
alkene functionalization; azidation; copper catalysis; radicals; trifluoromethylation
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Funding
- Ecole Polytechnique
- Nanyang Technological University
- Singapore Ministry of Education (Academic Research Fund Tier 1) [RG2/15]
- PHC Merlion grant [5.02.15]
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A protocol for the anti-Markovnikov hydrofunctionalization of alkenes has been developed by the use of a benzyl group as a traceless redox-active hydrogen donor. Under copper catalysis and in the presence of CF3- or N-3-containing hypervalent iodine reagents, a series of homoallylic alcohol derivatives were hydrofunctionalized regioselectivity. A similar principle was also applied to the hydrofunctionalization of alkenols.
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