Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 33, Pages 27533-27543Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b08398
Keywords
hollow nanogolf balls; NIR laser; localized surface plasmon resonance; photothermal therapy (PTT); cellular uptake
Funding
- National Institute on Aging of National Institutes of Health [AG028709]
- FUMEC
- AMC
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Hybrid nanocarriers with multifunctional properties have wide therapeutic and diagnostic applications. We have constructed hollow silica nanogolf balls (HGBs) and gold-embedded hollow Silica nanogolf balls (Au@SiO, HGBs) using the layer-by -layer approach on a symmetric polystyrene (PS) Janus template; the template consists ofsmaller' PS spheres attached to an oppositely chargdd large PS core. 'C Potential measurement supports the electric force-based template assisted synthesis mechanism. Electron microscopy, UV vis, and neat infrared (NIR) spectroscopy show that HGBs or Au@SiO2 HGBs are composed of a porous silica shell with an optional dense layer gold nanoparticles embedded in the silica shell. To visualize their cellular uptake and imaging potential, Au@SiO2 HGBs were loaded with quantum dots (QDs). Confocal fluorescent microscopy and atomic force microscopy imaging show reliable endocytosis of QD-loaded Au@SiO2 HGBs in adherent HeLa cells and circulating red blood cells (RBCs). Surface -enhanced Raman spectroscopy of Au@SiO2 FIGEs in RBC cells show enhanced intensity of the Raman signal specific to the RBcs' membrane specific spectral markers. Au@SiO2 HGBs show localized surface plasmon resonance and heat-induced HeLa cell death in the NIR range. These hybrid golf ball nanocarriers would have broad applications in personalized nanomedidne ranging from in vivo imaging to photothermal therapy.
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