Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 61, Issue 9, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00877-17
Keywords
carbapenemases; MDR Klebsiella oxytoca; plasmids; MBLs; KPC-2
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Funding
- National Natural Science Foundation of China [81501783]
- Ministry of Science and Technology [2015CB554200]
- China Postdoctoral Science Foundation [2017M613231]
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The nucleotide sequences of five plasmids from one Klebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed that bla(NDM-1) was carried on an IncX3 plasmid. The bla(IMP-4) and bla(KPC-2) genes were located on IncN and IncP-6 plasmids, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harboring plasmids among different enterobacterial species. We report for the first time, to our knowledge, coproducing NDM-1, KPC-2, and IMP-4 carbapenemases on a K. oxytoca isolate.
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