Journal
DNA REPAIR
Volume 56, Issue -, Pages 92-101Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2017.06.011
Keywords
Histone ubiquitination; BRCA1/BARD1; PRC1; RNF168; BRE1; DNA damage response
Categories
Funding
- NWO-CW TOP [714.012.001]
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DNA double strand breaks need to be repaired in an organized fashion to preserve genomic integrity. In the organization of faithful repair, histone ubiquitination plays a crucial role. Recent findings suggest an integrated model for DNA repair regulation through site-specific histone ubiquitination and crosstalk to other post translational modifications. Here we discuss how site-specific histone ubiquitination is achieved on a molecular level and how different multi-protein complexes work together to integrate different histone ubiquitination states. We propose a model where site-specific H2A ubiquitination organizes the spatio-temporal recruitment of DNA repair factors which will ultimately contribute to DNA repair pathway choice between homologous recombination and non-homologous end joining.
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