Journal
CELL CYCLE
Volume 16, Issue 16, Pages 1526-1533Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2017.1339850
Keywords
p16(Ink4a); senescence; biomarkers; senescence-associated -galactosidase (SA-Gal); healthspan
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Funding
- Everon Biosciences
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Age-related health decline has been attributed to the accumulation of senescent cells recognized in vivo by p16(Ink4a) expression. The pharmacological elimination of p16(Ink4a)-positive cells from the tissues of mice was shown to extend a healthy lifespan. Here, we describe a population of mesenchymal cells isolated from mice that are highly p16(INK4a)-positive are proficient in proliferation but lack other properties of cellular senescence. These data, along with earlier reports on p16(Ink4a)-positive macrophages, indicate that p16(Ink4a)-positive and senescent cell populations only partially intersect, therefore, extending the list of potential cellular targets for anti- aging therapies.
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