Journal
ANALYTICA CHIMICA ACTA
Volume 986, Issue -, Pages 1-11Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2017.07.043
Keywords
Biomarkers; Capillary electrophoresis; Solid-phase extraction; Microfluidics
Categories
Funding
- National Institutes of Health [R01 EB006124]
- Department of Chemistry and Biochemistry at Brigham Young University
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Microfluidics is a vibrant and expanding field that has the potential for solving many analytical challenges. Microfluidics show promise to provide rapid, inexpensive, efficient, and portable diagnostic solutions that can be used in resource-limited settings. Researchers have recently reported various microfluidic platforms for biomarker analysis applications. Sample preparation processes like purification, preconcentration and labeling have been characterized on-chip. Additionally, improvements in microfluidic separation techniques have been reported for molecular biomarkers. This review critically evaluates microfluidic sample preparation platforms and separation methods for biomarker analysis reported in the last two years. Key advances in device operation and ability to process different sample matrices in a variety of device materials are highlighted. Finally, current needs and potential future directions for microfluidic device development to realize its full diagnostic potential are discussed. (C) 2017 Elsevier B.V. All rights reserved.
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