Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 49, Pages 11771-11775Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201702867
Keywords
amide; amine; C-N activation; nickel catalysis; synthetic methods
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Funding
- China Scholarship Council
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A catalytic synthesis of amidines from amides has been established for the first time. The newly developed CO extrusion recombination process takes advantage of an inexpensive nickel(II) catalyst and provides the corresponding amidines with high efficiency. The intramolecular fragment coupling shows excellent chemoselectivity, starts from readily available amides, and provides a valuable alternative amidine synthesis protocol.
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