Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 27, Issue 16, Pages 3787-3793Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2017.06.065
Keywords
Melatonin; Intraocular pressure; Oxindole derivatives; Glaucoma treatment
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Funding
- Russian Foundation of Basic Research [14-03-01008]
- Grant of the President of the Russian Federation [NSh-5130.2014.3]
- Division of Chemistry and Materials Science of the Russian Academy of Sciences [OKhNM-9]
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The study represents the new findings at the crossroads of chemistry and medicine, particularly between medicinal and organic chemistry and ophthalmology. In this work we describe how the chemical reactivity of indolinone scaffold may be used to create small molecule ligands with strong biological response comparable with and larger than that of endogenous hormone. The synthesis of oxindole-based melatonin and 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT) analogues was proposed and their ability to influence intraocular pressure (IOP) was studied in vivo. Time-dependent study revealed the prolonged effect (more than 6 h) of the lead-compound. This effect in combination with high IOP reducing effect (41 +/- 6%) in low concentrations of the active compound (0.1 wt%) and with high water solubility represents a great potential of low-cost oxindole derivatives as potent antiglaucoma agents. (C) 2017 Elsevier Ltd. All rights reserved.
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