Journal
CARBOHYDRATE POLYMERS
Volume 174, Issue -, Pages 904-914Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.07.013
Keywords
UV-crosslinkable chitosan; Thermo-responsive hydrogel; In situ forming hydrogel; Photothermal carbon; NIR-triggered localized on-demand drug release
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Funding
- National Science Foundation of China [51372051, 51621091, 11372243, 11522219, 11532009]
- State Key Laboratory of Urban Water Resource and Environment of Harbin Institute of Technology [2016T503]
- HIT Environment and Ecology Innovation Special Funds [HSCJ201623]
- Innovation Talents of Harbin Science and Engineering [2013RFLXJ023]
- Fundamental Research Funds for Central Universities [HIT.IBRSEM.201302]
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Innovative drug delivery technologies based on smart hydrogels for localized on-demand drug delivery had aroused great interest. To acquire smart UV-crosslinkable chitosan hydrogel for NIR-triggered localized on-demanded drug release, a novel UV-crosslinkable and thermo-responsive chitosan was first designed and synthesized by grafting with poly N-isopropylacrylamide, acetylation of methacryloyl groups and embedding with photothermal carbon. The UV-crosslinkable unit (methacryloyl groups) endowed chitosan with gelation via UV irradiation. The thermo-responsive unit (poly N-isopropylacrylamide) endowed chitosan hydrogel with temperature-triggered volume shrinkage and reversible swelling/de-swelling behavior. The chitosan hybrid hydrogel embedded with photothermal carbon exhibited distinct NIR-triggered volume shrinkage (similar to 42% shrinkage) in response to temperature elevation as induced by NIR laser irradiation. As a demonstration, doxorubicin release rate was accelerated and approximately 40 times higher than that from non-irradiated hydrogels. The UV-crosslinkable and thermal-responsive hybrid hydrogel served as in situ forming hydrogel-based drug depot is developed for NIR-triggered localized on-demand release. (C) 2017 Elsevier Ltd. All rights reserved.
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