Journal
CLINICS IN LABORATORY MEDICINE
Volume 37, Issue 3, Pages 473-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cll.2017.06.002
Keywords
Melanoma; Spitz nevus; BAP-1 inactivated spitzoid nevus; Kinase gene fusion; Molecular; Comparative genomic hybridization
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Molecular evaluation of melanocytic tumors can be diagnostically useful to confirm malignancy or benignancy. Molecular tools are ancillary and supplemental to histopathologic evaluation and do not replace conventional microscopy. Immunohistochemistry, fluorescence in situ hybridization, array comparative genomic hybridization, and massively parallel short read sequencing, often referred to as next-generation sequencing, each provide varied (and often incomplete) additional information, and careful planning is necessary if tissue is limited.
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