Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1868, Issue 1, Pages 123-131Publisher
ELSEVIER
DOI: 10.1016/j.bbcan.2017.03.002
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Funding
- American Cancer Society [125303-PF-13-097-01-CCE]
- National Institutes of Health (NIH) [P50 CA168504, P50 CA165962, CA187918-02, CA210057-01, CA172461-04]
- Breast Cancer Research Foundation
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The PI3-kinase/AKT pathway integrates signals from external cellular stimuli to regulate essential cellular functions, and is frequently aberrantly activated in human cancers. Recent research demonstrates that tight regulation of the epigenome is critical in preserving and restricting transcriptional activation, which can impact cellular growth and proliferation. In this review we examine mechanisms by which the PI3K/AKT pathway regulates the epigenome to promote oncogenesis, and highlight how connections between PI3K/AKT and the epigenome may impact the future therapeutic treatment of cancers featuring a hyperactivated PI3K/AKT pathway. (C) 2017 Elsevier B.V. All rights reserved.
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