4.7 Review

Metabolism in time and space - exploring the frontier of developmental biology

Journal

DEVELOPMENT
Volume 144, Issue 18, Pages 3193-3198

Publisher

COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.150573

Keywords

Metabolism; Mitochondria; Aerobic glycolysis; Developmental plasticity; Nutrient sensing

Funding

  1. National Institutes of Health R35 Maximizing Investigators' Research Award (MIRA) from NIGMS [1R35GM119557]

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Despite the fact that metabolic studies played a prominent role in the early history of developmental biology research, the field of developmental metabolism was largely ignored following the advent of modern molecular biology. Metabolism, however, has recently re-emerged as a focal point of biomedical studies and, as a result, developmental biologists are once again exploring the chemical and energetic forces that shape growth, development and maturation. In May 2017, a diverse group of scientists assembled at the EMBO/EMBL Symposium 'Metabolism in Time and Space' to discuss how metabolism influences cellular and developmental processes. The speakers not only described how metabolic flux adapts to the energetic needs of a developing organism, but also emphasized that metabolism can directly regulate developmental progression. Overall, and as we review here, this interdisciplinary meeting provided a valuable forum to explore the interface between developmental biology and metabolism.

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