Journal
EMBO JOURNAL
Volume 36, Issue 18, Pages 2670-2683Publisher
WILEY
DOI: 10.15252/embj.201797135
Keywords
aging; metabolic disorders; neurodegeneration; nicotinamide adenine dinucleotide; poly ADP-ribose polymerase
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Funding
- Ecole Polytechnique Federale de Lausanne
- Swiss National Science Foundation [31003A-140780]
- AgingX of the Swiss Initiative for Systems Biology [51RTP0-151019]
- NIH [R01AG043930]
- Swiss National Science Foundation (SNF) [31003A_140780] Funding Source: Swiss National Science Foundation (SNF)
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Discovered in the beginning of the 20(th) century, nicotinamide adenine dinucleotide (NAD(+)) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include the sirtuin family of NAD(+)-dependent protein deacylases, widely recognized regulators of metabolic function and longevity. Altered NAD(+) metabolism is associated with aging and many pathological conditions, such as metabolic diseases and disorders of the muscular and neuronal systems. Conversely, increased NAD(+) levels have shown to be beneficial in a broad spectrum of diseases. Here, we review the fundamental aspects of NAD(+) biochemistry and metabolism and discuss how boosting NAD(+) content can help ameliorate mitochondrial homeostasis and as such improve healthspan and lifespan.
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