Journal
CARBOHYDRATE POLYMERS
Volume 172, Issue -, Pages 223-229Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.05.049
Keywords
Polysaccharide derivative; Chiral separation; Chiral stationary phase; HPLC; Immobilization
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Funding
- National Natural Science Foundation of China [51303175, 51373166]
- The Hundred Talents Program from the Chinese Academy of Sciences
- Program of Scientific Development of Jilin Province [20150204027GX, 20160414032GH]
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Traditional cellulose-based chiral stationary phases (CSPs) are prepared by physically coating cellulose derivatives onto substrates and only compatible with a very limited range of solvents as the mobile phase. Therefore, chemical immobilization of cellulose derivatives onto silica gel has been efficiently applied to improve the solvent compatibility of cellulose-based CSPs. Here we developed a novel approach to homogeneously modifying cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC). A series of carboxylic acid functionalized CDMPCs (CC-Xs) with controlled amounts and randomly distributed carboxylic acid groups was synthesized. CC-Xs were effectively immobilized onto amine-modified silica gel to afford immobilized CSPs. Compared to coated-type CSPs, immobilized CSPs significantly improved the solvent compatibility while maintaining similar chiral recognition abilities, but the introduction of excessive functional groups led to a deteriorated performance for columns. Moreover, a commercial drug, atenolol, was also sufficiently separated on the immobilized CSPs. (C) 2017 Elsevier Ltd. All rights reserved.
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