Journal
CLINICAL IMAGING
Volume 45, Issue -, Pages 105-110Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clinimag.2017.04.004
Keywords
Hyperpolarized helium MRI; Cystic fibrosis; Magnetic resonance imaging; Child; Infant
Funding
- Hartwell Foundation
- Vertex Pharmaceuticals Incorporated
- Siemens Healthcare
- R21 research grant [NIH R21 EB022309]
Ask authors/readers for more resources
Purpose: To develop and evaluate a protocol for hyperpolarized helium-3 (HHe) ventilation magnetic resonance imaging (MRI) of the lungs of non-sedated infants and children. Materials and methods: HHe ventilation MRI was performed on seven children <= 4years old. Contiguous 2D-spiral helium-3 images were acquired sequentially with a scan time of <= 0.2 s/slice. Results: Motion-artifact-free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained. Gas was homogeneously distributed in healthy individuals; focal ventilation defects were found in patients with respiratory diseases. Conclusion: HHe ventilation MRI can aid assessment of pediatric lung disease even at a young age. (C) 2017 The Authors. Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available