Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 65, Issue 9, Pages 869-873Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c17-00163
Keywords
Scrophularia ningpoensis; iridoid; pyrrolidin-2-one; anti-inflammatory
Funding
- National Natural Science Foundation of China [U1608282]
- Basic Scientific Research Fund of Northeastern University, China [N142002001, N152006002]
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Five new compounds including five iridoids (1-5) and six known compounds were isolated from the rhizomes of Scrophularia ningpoensis. Their structures were determined by extensive NMR and IR, MS spectroscopic data analyses. The anti-inflammatory, antibacterial, antifungal, and cytotoxic activities of the isolated compounds were evaluated. Compound 11 exhibited significant inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophage cells.
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