Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 163, Issue 4, Pages 461-464Publisher
SPRINGER
DOI: 10.1007/s10517-017-3828-5
Keywords
Clock gene polymorphism 3111T/C; insomnia; circadian rhythms
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Funding
- Russian Foundation for Basic Research [16-34-00093]
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Comparative analysis of the frequency distributions of genotypes and alleles of 3111T/C Clock gene polymorphism was carried out in climacteric Caucasian women with and without insomnia. Genotype TT is more incident in women with insomnia (55.5% vs. 42.6% in the control). Allele T predominated in the control and study group and its frequency is higher in women with insomnia. The OR for the risk of insomnia realization is 1.78 (95%CI 1.16-2.75). No association between genotypes and complaints of patients with insomnia is detected.
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