Journal
VIRUSES-BASEL
Volume 9, Issue 10, Pages -Publisher
MDPI AG
DOI: 10.3390/v9100290
Keywords
Bcl-2; apoptosis; autophagy; structural biology; poxvirus; herpesvirus; asfarvirus; iridovirus; adenovirus; host-pathogen interactions
Categories
Funding
- National Health and Medical Research Council Australia [APP1007918]
- Australian Research Council [FT130101349]
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Members of the B cell lymphoma-2 (Bcl-2) family are pivotal arbiters of mitochondrially mediated apoptosis, a process of fundamental importance during tissue development, homeostasis, and disease. At the structural and mechanistic level, the mammalian members of the Bcl-2 family are increasingly well understood, with their interplay ultimately deciding the fate of a cell. Dysregulation of Bcl-2-mediated apoptosis underlies a plethora of diseases, and numerous viruses have acquired homologs of Bcl-2 to subvert host cell apoptosis and autophagy to prevent premature death of an infected cell. Here we review the structural biology, interactions, and mechanisms of action of virus-encoded Bcl-2 proteins, and how they impact on host-virus interactions to ultimately enable successful establishment and propagation of viral infections.
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