Journal
VIRUSES-BASEL
Volume 9, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/v9060143
Keywords
Zika virus; animal models; immunology; vaccines; congenital Zika syndrome
Categories
Funding
- Robert Wood Johnson Foundation
- Harold Amos Medical Faculty Development Program [73307]
- National Institute of Allergy and Infectious Diseases Cooperative Centers on Human Immunity (NIAID) [U19 AI-110820]
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Zika is a rapidly emerging public health threat. Although clinical infection is frequently mild, significant neurological manifestations have been demonstrated in infants born to Zika virus (ZIKV) infected mothers. Due to the substantial ramifications of intrauterine infection, effective counter-measures are urgently needed. In order to develop effective anti-ZIKV vaccines and therapeutics, improved animal models and a better understanding of immunological correlates of protection against ZIKV are required. This review will summarize what is currently known about ZIKV, the clinical manifestations and epidemiology of Zika as well as, the development of animal models to study ZIKV infection, host immune responses against ZIKV, and the current state of development of vaccines and therapeutics against ZIKV.
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