Journal
VIRUSES-BASEL
Volume 9, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/v9080217
Keywords
telomere; EBV; telomerase; ALT
Categories
Funding
- Swedish Cancer Society
- Swedish Medical Research Council
- Konung Gustav V:s och Drottning Viktoria Frimurarstiftelse
- Karolinska Institutet, Stockholm, Sweden
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The acquisition of unlimited proliferative potential is dependent on the activation of mechanisms for telomere maintenance, which counteracts telomere shortening and the consequent triggering of the DNA damage response, cell cycle arrest, and apoptosis. The capacity of Epstein Barr virus (EBV) to infect B-lymphocytes in vitro and transform the infected cells into autonomously proliferating immortal cell lines underlies the association of this human gamma-herpesvirus with a broad variety of lymphoid and epithelial cell malignancies. Current evidence suggests that both telomerase-dependent and -independent pathways of telomere elongation are activated in the infected cells during the early and late phases of virus-induced immortalization. Here we review the interaction of EBV with different components of the telomere maintenance machinery and the mechanisms by which the virus regulates telomere homeostasis in proliferating cells. We also discuss how these viral strategies may contribute to malignant transformation.
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