Journal
TRANSCRIPTION-AUSTIN
Volume 8, Issue 1, Pages 61-66Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21541264.2016.1265702
Keywords
casein kinase 2; chromatin; KMT2D; NCoR; NICD; Notch; RBPJ; SHARP; transcription; transcriptional activation; transcriptional repression
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Funding
- Heisenberg program [BO 1,639/5-1]
- Deutsche Forschungsgemeinschaft (DFG)
- Excellence Cluster for Cardio Pulmonary System (ECCPS)
- Max-Planck society
- DFG [TRR81, SFB 1074/A3]
- BMBF (Federal Ministry of Education and Research, research nucleus SyStAR)
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RBPJ is the central transcription factor that controls the Notch-dependent transcriptional response by coordinating repressing histone H3K27 deacetylation and activating histone H3K4 methylation. Here, we discuss the molecular mechanisms how RBPJ interacts with opposing NCoR/HDAC-corepressing or KMT2D/UTX-coactivating complexes and how this is controlled by phosphorylation of chromatin modifiers.
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