Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 38, Pages 32545-32553Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b09796
Keywords
co-electrospun; scaffolds; TGF-beta 1 inhibitor; antiscar; wound healing
Funding
- National Science Foundation of China [81361140345, 31470911, 81673039, 51373043, 51373082, 51673103]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA09030305, XDA09030307]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- Taishan Scholars Program of Shandong Province, China [ts20120528]
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Hypertrophic scarring (HS) is a disorder that occurs during wound healing and seriously depresses the quality of human life. Scar-inhibiting scaffolds, though bringing promise to HS prevention, face problems such as the incompatibility of the scaffold materials and the instability of bioactive molecules. Herein, we present a TGF-beta 1-inhibitor-doped poly(e-caprolactone) (PCL)/gelatin (PG) coelectrospun nanofibrous scaffold (PGT) for HS prevention during wound healing. The appropriate ratio of PCL to gelatin can avoid individual defects of the two materials and achieve an optimized mechanical property and biocompatibility. The TGF-beta 1 inhibitor (SB-525334) is a small molecule and is highly stable during electrospinning and drug release processes. The PGT effectively inhibits fibroblast (the major cell type contributing to scar formation) proliferation in vitro and successfully prevents HS formation during the healing of full-thickness model wounds on rabbit ear. Our strategy offers an excellent solution for potential large-scale production of scaffolds for clinical HS prevention.
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