4.3 Article

Rhodium-catalyzed Synthesis of 1-Arylisoquinoline Derivatives through Annulative Coupling of 3-Aryl-1,2-benzisoxazoles and Alkynes

Journal

CHEMISTRY LETTERS
Volume 46, Issue 10, Pages 1512-1514

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.170618

Keywords

C-H activation; Rhodium; Isoquinoline

Funding

  1. JSPS KAKENHI [JP 17H01202, JP 17H06092]
  2. Grants-in-Aid for Scientific Research [17H01202, 17H06092] Funding Source: KAKEN

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Direct annulative coupling of 3-aryl-1,2-benzisoxazoles and alkynes efficiently proceeds in the presence of a Cp*Rh(III) catalyst to produce 2-(1-isoquinolinyl)phenols of interest in medicinal chemistry as well as materials chemistry. The products may also be useful precursors of quinoline-based bidentate ligands.

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