Journal
AUTOIMMUNITY REVIEWS
Volume 16, Issue 9, Pages 970-979Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2017.07.011
Keywords
HLA-association; Genetic predisposition; Immune-mediated inflammatory disorders; Psoriasis vulgaris; Autoimmune response; T-cell receptor specificity
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Funding
- Deutsche Forschungsgemeinschaft [Pr241/5-1]
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Chronic immune-mediated disorders (IMDs) constitute a major health burden. Understanding IMD pathogenesis is facing two major constraints: Missing heritability explaining familial clustering, and missing autoantigens. Pinpointing IMD risk genes and autoimmune targets, however, is of fundamental importance for developing novel causal therapies. The strongest association of all IMDs is seen with human leukocyte antigen (HLA) alleles. Using psoriasis as an IMD model this article reviews the pathogenic role HLA molecules may have within the polygenic predisposition of IMDs. It concludes that disease-associated HLA alleles account for both missing heritability and autoimmune mechanisms by facilitating tissue-specific autoimmune responses through autoantigen presentation. (C) 2017 The Author. Published by Elsevier B.V.
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