Two Zinc(II) and Nickel(II)-based Complexes: Anti Breast Cancer Activity

Two zinc(II) and nickel(II) based coordination polymers, {[Zn(bibp)(MoO4)](H2O)(2)}(n) (1) [bibp = 4,4-bis(imidazol-1-yl)-biphenyl] and [Ni-2(CN)(4)(phen)(2)](n) (2) (phen = 1,10-phenanthroline), were synthesized and structurally characterized under solvothermal conditions. Compound 1 can be viewed as the connection of the 1D W-type chain [Zn(trans-bibp)] with the MoO42- anion to form a uninodal 4-connected net, whereas 2 features one-dimensional Ni-II cyanide chains decorated either with linear Ni(CN)(4) side chains or with 1,10-phenanthroline ligands bound directly to the Ni-II sites of the parent chain. In addition, in vitro anticancer activities of compounds 1 and 2 on four human breast cancer cells (MDA-MB-231, MDA-MB-468, SK-BR-3, and MCF7) was further determined.