Journal
DALTON TRANSACTIONS
Volume 46, Issue 33, Pages 10847-10858Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7dt02107k
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Funding
- National Science Centre Poland (NCN) [DEC-2012/05/B/ST5/00300, DEC-2012/04/A/ST5/00609]
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Three types, esters, amides and 1,2,3-triazoles, of ferrocenyl-podophyllotoxin conjugates were synthesised, and their anticancer activity was evaluated. We observed that the most potent ferrocenyl derivatives were esters. Esters 15, 16 and 17 acted in a similar way to podophyllotoxin, i.e. reduced the number of G1 phase cells and induced G2/M blockage, while esters 14 and 18 and amide 19 blocked cells in S phase in a similar manner to etoposide.
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