Journal
ZEBRAFISH
Volume 14, Issue 1, Pages 69-72Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/zeb.2016.1321
Keywords
transgenesis; neurodegenerative disease; Tol2 gateway; disease model
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Funding
- Snow Foundation
- Rebecca Cooper Medical Research Foundation
- MND Research Institute of Australia [GIA1409, GIA1638]
- BitFury.org
- National Health and Medical Research Council (NHMRC) [GNT1034816]
- Macquarie University
- ARC [DP140103233]
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Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration.
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