Journal
CHEMISTRY & BIODIVERSITY
Volume 14, Issue 9, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201700184
Keywords
Heracleum dissectum; Ethnic herbs; Alkaloids; Structure elucidation; Anti-inflammation
Funding
- Start Scientific Research Fund for Returned Overseas Students of Ministry of Education of China [[2012] 940]
- Natural Science Foundation of Shaanxi Province [2015JM8413]
- National Natural Science Foundation of China [81673564]
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Using various chromatographic methods, a new piperidinone alkaloid, (3S)-3-{4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenoxy}piperidin-2-one (1), together with 10 known compounds, bergapten (2), xanthotoxol (3), isopimpinellin (4), isobergapten (5), heratomol-6-O-beta-d-glucopyranoside (6), scopoletin (7), apterin (8), 3-methoxy-4-beta-d-glucopyranosyloxypropiophenone, (praeroside; 9), tachioside (10) and coniferin (11), were isolated from roots of Heracleum dissectum Ledeb. Their structures were elucidated on the basis of physicochemical properties and the detailed interpretation of various spectroscopic data. All the isolated compounds were screened for anti-inflammatory activity in vitro. As the results, compound 1 and 8 showed significantly inhibitory activity on nitric oxide production in RAW264.7 cells.
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