Journal
YEAST
Volume 35, Issue 1, Pages 5-20Publisher
WILEY
DOI: 10.1002/yea.3242
Keywords
hybridization; yeast; comparative genomics; pathogens; emergence of virulence
Categories
Funding
- Spanish Ministry of Economy and Competitiveness, 'Centro de Excelencia Severo Ochoa' - European Regional Development Fund [SEV-2012-0208, BFU2015-67107]
- CERCA programme / Generalitat de Catalunya
- European Union
- ERC Seventh Framework Programme (FP7) [FP7-PEOPLE-2013-ITN-606786 'ImResFun', ERC-2012-StG-310325]
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [H2020-MSCA-ITN-2014-642095]
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Hybridization between different species can result in the emergence of new lineages and adaptive phenotypes. Occasionally, hybridization in fungal organisms can drive the appearance of opportunistic lifestyles or shifts to new hosts, resulting in the emergence of novel pathogens. In recent years, an increasing number of studies have documented the existence of hybrids in diverse yeast clades, including some comprising human pathogens. Comparative and population genomics studies performed on these clades are enabling us to understand what roles hybridization may play in the evolution and emergence of a virulence potential towards humans. Here we survey recent genomic studies on several yeast pathogenic clades where hybrids have been identified, and discuss the broader implications of hybridization in the evolution and emergence of pathogenic lineages. (c) 2017 The Authors. Yeast published by John Wiley & Sons, Ltd.
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