Journal
AUTOIMMUNITY REVIEWS
Volume 16, Issue 10, Pages 1044-1048Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2017.07.021
Keywords
Dermatomyositis; Polymyositis; Pathogenesis; Multi-omics
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Funding
- National Natural Science Foundation of China [81373206, 81401357, 81671622]
- Independent Innovation Projects of Central South University [2016zzts131]
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Idiopathic inflammatory myopathies (IIM) are a group of rare and heterogeneous autoimmune diseases, and the most common subtypes are dermatomyositis (DM) and polymyositis (PM). Despite extensive efforts, the underlying mechanism of IIM remains unclear. Recent efforts to understand the pathogenesis of IIM have included genomics, epigenetics, transcriptomics, proteomics and autoantibody studies. This review focuses on recent studies in DM/PM research based on multi-omics. This integrated analysis of multi-omics profiling will provide useful in-sights into DM/PM pathogenesis and recommendations for therapeutic targets and biomarkers development (C) 2017 Elsevier B.V. All rights reserved.
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