Journal
ACS NANO
Volume 11, Issue 10, Pages 10124-10134Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b04685
Keywords
conjugated polymer nanoparticles; molecular engineering; theranostic platform; tumor; photoacoustic imaging; photothermal therapy
Categories
Funding
- National University of Singapore [R279-000-482-133]
- NRF Investigatorship [R279-000-444-281]
- Natural Science Foundation of China [81571745, 81401521, 81327801]
- Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province [2014B030301013]
- Singapore NRF Competitive Research Program [R279-000-483-281]
- Major State Basic Research Development Program of China (973 Program) [2015CB755500]
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Conjugated polymer nanoparticles (CP NPs) are emerging candidates of all-in-one theranostic nanoplat-forms with dual photoacoustic imaging (PA) and photothermal therapy (PTT) functions. So far, very limited molecular design guidelines have been developed for achieving CPs with highly efficient PA and PTT performance. Herein, by designing CP1, CP2, and CP3 using different electron acceptors (A) and a planar electron donor (D), we demonstrate how the D A strength affects their absorption, emission, extinction coefficient, and ultimately PA and PTT performance. The resultant CP NPs have strong PA signals with high photo thermal conversion efficiencies and excellent biocompatibility in vitro and in vivo. The CP3 NPs show a high PA signal to background ratio of 47 in U87 tumor-bearing mice, which is superior to other reported PA/PTT theranostic agents. A very small IC50 value of 0.88 mu g/mL (CP3 NPs) was obtained for U87 glioma cell ablation under laser irradiation (808 nm, 0.8 W/cm(2), 5 min). This study shows that CP NP based theranostic platforms are promising for future personalized nanomedicine.
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