Journal
WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY
Volume 21, Issue 4, Pages 259-266Publisher
TERMEDIA PUBLISHING HOUSE LTD
DOI: 10.5114/wo.2017.72382
Keywords
HNSCC; biomarkers; lncRNA; head and neck
Categories
Funding
- Greater Poland Cancer Centre [21/2015 (113), 13/2016 (128)]
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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cause of cancer mortality in the world. Some progress has been made in the therapy of HNSCC, however treatment remains unsatisfactory. Recent studies have shown that different types of long non-coding RNAs (lncRNAs) are dysregulated in HNSCC and correlate with tumor progression, lymph node metastasis, clinical stage and poor prognosis. lncRNAs are a class of functional RNA molecules that can not be translated into proteins but can modulate the activity of transcription factors or regulate changes in chromatin structure. The lncRNAs might have potential of biomarker in HNSCC diagnosis, prognosis, prediction and targeted treatment. In this review we describe the potential role of lncRNAs as new biomarkers and discuss their features including source of origin, extraction methods, stability, detection methods and data normalization and potential function as biomarkers in HNSCC.
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