Evaluation of serum D-dimer, fibrinogen, and CA19-9 for postoperative monitoring and survival prediction in resectable pancreatic carcinoma

Background: We sought to investigate the efficacy of serum D-dimer, fibrinogen, and CA19-9 for postoperative monitoring and prediction of survival in patients with resectable pancreatic carcinoma (PC). Methods: One hundred and nineteen patients with resectable PC were enrolled. Serum D-dimer, fibrinogen, and CA19-9 values were analyzed before surgery and at the stages of relapse-free and progression disease. Results: D-dimer, fibrinogen, and CA19-9 were significantly higher at the active stage of PC than those at the relapse-free stage [1059.2 (1690.1) ng/ml vs 485.18 (289.84) ng/ml, (3.71 +/- 0.83) g/l vs (2.75 +/- 0.52) g/l, 207.2 (681.8) U/ml vs 24.5 (30) U/ml, respectively, p < 0.01]. Patients with elevated preoperative D-dimer had significantly shorter overall survival (18.9 +/- 1.9 months vs 29.2 +/- 2.6 months, p < 0.01) and progression-free survival (10.6 +/- 1.2 months vs 20.4 +/- 2.4 months, p < 0.01) than did those with low D-dimer. The correlation between CA19-9 values and survival depended on the threshold value of CA19-9: when the threshold value was 37 U/ml, there was no correlation between CA19-9 and survival; when the threshold value was 253.8 U/ml (median CA19-9 for the enrolled patients), patients with elevated preoperative CA19-9 had significantly shorter overall survival (19.9 +/- 2. 1 months vs 29.0 +/- 2. 7 months) and progression-free survival (11.5 +/- 1.5 months vs 21.0 +/- 2. 6 months) than did the patients with low CA19-9 (p < 0.01); when the threshold value was 1000 U/ml, the overall survival was 15.5 +/- 2.3 months vs 28.0 +/- 2. 0 months and the progression-free survival 8.9 +/- 1.9 months vs 19.1 +/- 1.9 months (p < 0.01). There was no correlation between fibrinogen and overall survival (25.8 +/- 2.1 months vs 21.2 +/- 2.9 months; p = 0.096) and progression-free survival (17.8 +/- 2.1 months vs 12.7 +/- 1.7 months; p = 0.168). Conclusions: For postoperative monitoring of patients with resectable PC, D-dimer, fibrinogen, and CA19-9 may be used as markers for monitoring disease relapse, but only preoperative D-dimer could predict survival.