Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 39, Issue -, Pages 48-56Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2017.09.004
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Funding
- Portuguese Foundation for Science and Technology (PCT) [PTDC/BBB-BSS/6471/2014]
- COMPETE [POCI-01-0145-FEDER-006684]
- BioTecNorte operation - European Regional Development Fund [NORTE-01-0145-FEDER-000004]
- [UID/BIO/04469/2013 unit]
- Fundação para a Ciência e a Tecnologia [PTDC/BBB-BSS/6471/2014] Funding Source: FCT
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The complex heterogeneous structure of biofilms confers to bacteria an important survival strategy. Biofilms are frequently involved in many chronic infections in consequence of their low susceptibility to antibiotics as well as resistance to host defences. The increasing need of novel and effective treatments to target these complex structures has led to a growing interest on bacteriophages (phages) as a strategy for biofilm control and prevention. Phages can be used alone, as a cocktail to broaden the spectra of activity, or in combination with other antimicrobials to improve their efficacy. Here, we summarize the studies involving the use of phages for the treatment or prevention of bacterial biofilms, highlighting the biofilm features that can be tackled with phages or combined therapy approaches.
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