Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1862, Issue 10, Pages 1188-1196Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2017.06.005
Keywords
Lipid droplet; LD; Contact site; Lipidic bridge; Tether; Seipin
Funding
- European Union ERC CoG [646604]
- DFG [SFB 1190]
- Volkswagen Stiftung grant [93092]
- European Union's Horizon research and innovation programme under the Marie Sklodovska-Curie grant [705853]
- European Research Council (ERC) [646604] Funding Source: European Research Council (ERC)
- Marie Curie Actions (MSCA) [705853] Funding Source: Marie Curie Actions (MSCA)
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Lipid droplets (LDs) store lipids and hence serve as energy reservoir and as a source for building-blocks for the organelle membrane systems. LD biology therefore depends on tight communication with other organelles. The unique architecture of LDs, consisting of a neutral lipid core shielded by a phospholipid-monolayer, is however an obstacle to bulk-exchange of bilayer-bounded vesicles with other organelles. In recent years, it is emerging that contact sites, places where two organelles are positioned in close proximity allowing vesicle-independent communication, are an important way to integrate LDs into the organellar landscape. However, few LD contact sites have been studied in depth and our understanding of their structure, extent and function is only starting to emerge. Here, we highlight recent findings on the functions of LD contact sites and on the proteins involved in their formation and hypothesize about the unique characteristics of the contact sites formed by these intriguing organelles. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.
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