Journal
CELLULAR REPROGRAMMING
Volume 19, Issue 5, Pages 324-330Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/cell.2017.0020
Keywords
Neuropilin-1; dental pulp stem cell; odontoblast differentiation; Wnt/beta-catenin
Funding
- Graduate Student Innovation of Science and Technology Project - Jiangsu Province [SJLX16_0567]
- Graduate Student Innovation of Science and Technology Project - Nantong University [YKC16092]
- National Natural Science Foundation of China [81401365]
- Nantong Science and Technology Project [MS12015056, qyz15037, qyz15027]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Ask authors/readers for more resources
Neuropilin-1 (NRP1) is one of the members of neuropilin family. It can combine with disparate ligands involved in regulating cell proliferation, apoptosis, and differentiation. The binding of NRP1 to Sema3A stimulates osteoblast differentiation through the classical Wnt/beta-catenin pathway. However, the functions of NRP1 in dental pulp stem cells (DPSCs) are not clear. The aim of our study was to investigate how NRP1 controlled odontoblast differentiation in DPSCs and clarified the underlying mechanisms. NRP1 expression was increased in time-dependent manner along with cell odontoblast differentiation. Overexpression of NRP1 upregulated dentin matrix protein-1, dentin sialophosphoprotein, alkaline phosphatase protein level, and mineralization in DPSCs, while knockdown of NRP1 induced the opposite effects. SiNRP1 similar to DKK1 availably blocked classical Wnt/beta-catenin signaling and odontoblast differentiation. In summary, NRP1, as a promoter of odontoblast differentiation, regulates DPSCs via the classical Wnt/beta-catenin pathway.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available