Journal
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
Volume 33, Issue 11, Pages -Publisher
SPRINGER
DOI: 10.1007/s11274-017-2366-7
Keywords
5-Aminolevulinic acid; Enzymatic transformation; Metabolic engineering; Microbial cell factory; Photodynamic therapy
Categories
Funding
- Fundamental Research Funds for the Central Universities [JUSRP51707A]
- National Natural Science Foundation of China [31670092]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_15R26]
Ask authors/readers for more resources
5-Aminolevulinic acid (5-ALA) is the precursor for the biosynthesis of tetrapyrrole compounds and has broad applications in the medical and agricultural fields. Because of the disadvantages of chemical synthesis methods, microbial production of 5-ALA has drawn intensive attention and has been regarded as an alternative in the last years, especially with the rapid development of metabolic engineering and synthetic biology. In this mini-review, recent advances on the application and microbial production of 5-ALA using novel biological approaches (such as whole-cell enzymatic-transformation, metabolic pathway engineering and cell-free process) are described and discussed in detail. In addition, the challenges and prospects of synthetic biology are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available