Journal
AGEING RESEARCH REVIEWS
Volume 39, Issue -, Pages 78-86Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2017.03.001
Keywords
Calorie restriction; Protein restriction; Low protein high carbohydrate; Methionine restriction; Aging; Lifespan
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Funding
- National Health and Medical Research Council of Australia [571328, 1084267, 1101913]
- Australian Research Council [160101119]
- Sydney Medical School Foundation
- Ageing and Alzheimers Research Institute
- National Health and Medical Research Council of Australia [1101913, 1084267] Funding Source: NHMRC
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Nearly a century of research has shown that nutritional interventions can delay aging and age-related diseases in many animal models and possibly humans. The most robust and widely studied intervention is caloric restriction, while protein restriction and restriction of various amino acids (methionine, tryptophan) have also been shown to delay aging. However, there is still debate over whether the major impact on aging is secondary to caloric intake, protein intake or specific amino acids. Nutritional geometry provides new perspectives on the relationship between nutrition and aging by focusing on calories, macronutrients and their interactions across a landscape of diets, and taking into account compensatory feeding in ad libitum-fed experiments. Nutritional geometry is a state-space modelling approach that explores how animals respond to and balance changes in nutrient availability. Such studies in insects and mice have shown that low protein, high carbohydrate diets are associated with longest lifespan in ad libitum fed animals suggesting that the interaction between macronutrients may be as important as their total intake. (C) 2017 Elsevier B.V. All rights reserved.
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