Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 23, Issue 11, Pages 1974-1979Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v23.i11.1974
Keywords
Artificial liver; Clinical trial; Hepatocytes; Pluripotent stem cells; Bioreactors
Categories
Funding
- Baxter International Foundation/Keck Summer Research Fellowship Award
- California Institute for Regenerative Medicine [RT3-07670]
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There is currently a pressing need for alternative therapies to liver transplantation. The number of patients waiting for a liver transplant is substantially higher than the number of transplantable donor livers, resulting in a long waiting time and a high waiting list mortality. An extracorporeal liver support system is one possible approach to overcome this problem. However, the ideal cell source for developing bioartificial liver (BAL) support systems has yet to be determined. Recent advancements in stem cell technology allow researchers to generate highly functional hepatocyte-like cells from human pluripotent stem cells (hPSCs). In this mini-review, we summarize previous clinical trials with different BAL systems, and discuss advantages of and potential obstacles to utilizing hPSC-derived hepatic cells in clinical-scale BAL systems.
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