Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 40, Issue -, Pages 47-56Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2017.05.017
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Funding
- Queensland Government Accelerate Fellowship
- University of Queensland International Postgraduate Research Scholarship
- Bioplatforms Australia
- New South Wales (NSW)
- NSW Government's Department of Primary Industries
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Isoprenoids (terpenes/terpenoids) have many useful industrial applications, but are often not produced at industrially viable level in their natural sources. Synthetic biology approaches have been used extensively to reconstruct metabolic pathways in tractable microbial hosts such as yeast and re-engineer pathways and networks to increase yields. Here we review recent advances in this field, focusing on central carbon metabolism engineering to increase precursor supply, redirecting carbon flux for production of C10, C15, or C20 isoprenoids, and chemical decoration of high value diterpenoids (C20). We also overview other novel synthetic biology strategies that have potential utility in yeast isoprenoid pathway engineering. Finally, we address the question of what is required in the future to move the field forwards.
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